In subcutaneous xenograft models utilizing NSCLC (NCI-H358) and colorectal cancer (SW837) cell lines, daily oral administration of SONE-333 resulted in dose-dependent tumor regression. At well-tolerated doses, SONE-333 achieved >90% tumor growth inhibition (TGI) and complete tumor regression in 40% of NSCLC models, outperforming standard-of-care covalent inhibitors at equivalent dosing.
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Where precision is non-negotiable.