Neoepobin Patched | [new]

J.D. Vance(^1,2), S.P. Harimoto(^1), L.K. Chen(^3), A.M. Reyes(^1) Affiliations: (^1)Department of Biomedical Engineering, Stanford University; (^2)Chan Zuckerberg Biohub; (^3)Institute for Pain Research, Johns Hopkins University Correspondence: jvance@bioeng.stanford.edu

: Treating low red blood cell counts (anemia) caused by chronic kidney disease, chemotherapy, or certain HIV medications. neoepobin patched

| Metric | Unpatched Neoepobin (n=20) | | | :--- | :--- | :--- | | BBB Penetration (AUC ratio) | 0.12 | 0.89 | | Cardiac Events (QT prolongation) | 25% (5/20) | 0% (0/20) | | Liver Enzyme Elevation (ALT > 3x) | 30% (6/20) | 5% (1/20) | | 12-Week PSP Rating Scale (improvement) | -2.1 (decline) | +6.4 (improvement) | | Cerebrospinal fluid (CSF) ErbB4 activation | Low / Inconsistent | High / Sustained | Chen(^3), A