The gameplay mechanics in Hitman (2007) are similar to those of its predecessors, with a few notable improvements. Players can choose to play the game in a variety of modes, including:

Below is a sample index for Hitman (2007), including some of the game's key characters, levels, and game mechanics:

Agent 47 finds himself framed in a conspiracy involving the Russian President, shifting him from a predator to a fugitive.

, an assassin for a clandestine organization known as "The Agency" (or "The Organization"), is hired to kill the Russian President, Mikhail Belicoff The Setup:

The indexing system of Hitman: Blood Money (2007) is a textbook example of a in mid-2000s game engines. It balances speed, obfuscation, and console constraints but sacrifices transparency and moddability. Its simplicity has allowed a robust modding scene, and its design directly influenced later Glacier 2 engine (Hitman: Absolution, Hitman 2016) which uses a two-level hash + chunk system .