However, in situations where the threat is too great, or the body feels overwhelmed, the freeze response is activated. This response is mediated by the parasympathetic nervous system (PNS), which counters the sympathetic nervous system's (SNS) "fight or flight" response. The PNS promotes relaxation, reducing stress hormones and heart rate, and inducing a state of immobility.
The dPAG is modulated by opioid and cannabinoid systems. The Freeze240316 data support investigating pharmacological agents (e.g., naloxone? or low-dose cannabinoids?) that could shorten pathologic freezing in trauma-exposed individuals. freeze240316hazelmoorestressresponsexxx new