Change your backend from Vulkan to OpenGL . While OpenGL might be slightly slower on some hardware, it is significantly more stable and often resolves "device lost" errors entirely.

If the issue persists across backends (D3D, OpenGL, and Vulkan), the problem is likely hardware-related (failing GPU or failing Power Supply Unit) or a corrupted Dolphin installation. Try downloading a fresh portable version of Dolphin to rule out configuration corruption.

Dolphin's Vulkan backend may attempt to allocate more GPU memory than available, especially when: