If you edited sasl_passwd or transport maps, you must run postmap /etc/postfix/filename and then postfix reload for the changes to take effect.
By methodically isolating the transport—whether Dovecot, Amavis, Maildrop, or a custom script—you can convert the "unknown" into a known, actionable fix. And once resolved, safeguard your configuration to ensure that the next system update doesn’t leave your mail queue suspended once again. If you edited sasl_passwd or transport maps, you
Check logs (primary debugging step)